› 2i0v

X-ray diffraction
2.8Å resolution

c-FMS tyrosine kinase in complex with a quinolone inhibitor

Released:
DOI: 10.2210/pdb2i0v/pdb
PDB entry 2i0v coloured by chain, front view.
PDB entry 2i0v coloured by chain, side view.
PDB entry 2i0v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.
Schubert C, Schalk-Hihi C, Struble GT, Ma HC, Petrounia IP, Brandt B, Deckman IC, Patch RJ, Player MR, Spurlino JC, Springer BA
J Biol Chem 282 4094-101 (2007)
PMID: 17132624

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139513 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 335 amino acids
Theoretical weight: 38.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07333 (Residues: 538-922; Coverage: 35%)
Gene names: CSF1R, FMS
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand 6C3 1 x 6C3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: R3
Unit cell:
a: 82.199Å b: 82.199Å c: 143.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.266 0.237 0.296
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

CSF-1 receptor signaling in myeloid cells.
Stanley et al. (2014)
6 more

4 mentions without citation

Structural basis for reversible photoswitching in Dronpa.
Andresen et al. (2007)
3 more