› 2i5o

Solution NMR

Solution Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Y-Polymerase Eta

Released:
DOI: 10.2210/pdb2i5o/pdb
PDB entry 2i5o coloured by chain, ensemble of 15 models, front view.
PDB entry 2i5o coloured by chain, ensemble of 15 models, side view.
PDB entry 2i5o coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta.
Bomar MG, Pai MT, Tzeng SR, Li SS, Zhou P
EMBO Rep 8 247-51 (2007)
PMID: 17304240

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195100 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA polymerase eta Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 4.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y253 (Residues: 628-662; Coverage: 5%)
Gene names: POLH, RAD30, RAD30A, XPV
Sequence domains: Ubiquitin-Binding Zinc Finger

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Structure originally calculated by torsion angle dynamics and refined by water refinement.
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Ubiquitin-binding domains - from structures to functions.
Dikic et al. (2009)
20 more

16 mentions without citation

An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η.
Yang W. (2014)
15 more