› 2ic5

X-ray diffraction
1.9Å resolution

Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.

Released:
DOI: 10.2210/pdb2ic5/pdb
PDB entry 2ic5 coloured by chain, front view.
PDB entry 2ic5 coloured by chain, side view.
PDB entry 2ic5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Yang X, Zao Y, Elkins J, Gileadi C, Burgess N, Colebrook S, Gileadi O, Fedorov O, Bunkoczi G, Sundstrom M, Arrowsmith C, Weigelt J, Edwards A, von Delft F, Doyle D, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related C3 botulinum toxin substrate 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 180 amino acids
Theoretical weight: 19.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60763 (Residues: 1-178; Coverage: 93%)
Gene name: RAC3
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

5 bound ligands:
Ligand MG 2 x MG
Ligand CL 2 x CL
Ligand GNP 1 x GNP
Ligand BTB 1 x BTB
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 53.755Å b: 81.583Å c: 84.381Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.155 0.153 0.2
Expression system: Escherichia coli

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