› 2idh

X-ray diffraction
2.28Å resolution

Crystal Structure of human FE65 WW domain

Released:
DOI: 10.2210/pdb2idh/pdb
PDB entry 2idh coloured by chain, front view.
PDB entry 2idh coloured by chain, side view.
PDB entry 2idh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for polyproline recognition by the FE65 WW domain.
Meiyappan M, Birrane G, Ladias JAA
J Mol Biol 372 970-980 (2007)
PMID: 17686488

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126155 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid beta precursor protein binding family B member 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 38 amino acids
Theoretical weight: 4.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00213 (Residues: 253-289; Coverage: 5%)
Gene names: APBB1, FE65, RIR
Sequence domains: WW domain

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand PG4 7 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P6322
Unit cell:
a: 75.61Å b: 75.61Å c: 226.489Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.217 0.282
Expression system: Escherichia coli

Quick links

Citations

8 review citations

ABL tyrosine kinases: evolution of function, regulation, and specificity.
Colicelli J. (2010)
7 more

4 mentions without citation

Structural basis for polyproline recognition by the FE65 WW domain.
Meiyappan et al. (2007)
3 more