› 2ig7

X-ray diffraction
1.8Å resolution

Crystal structure of Human Choline Kinase B

Released:
DOI: 10.2210/pdb2ig7/pdb
PDB entry 2ig7 coloured by chain, front view.
PDB entry 2ig7 coloured by chain, side view.
PDB entry 2ig7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rabeh WM, Tempel W, Nedyalkova L, Wasney G, Landry R, Vedadi M, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + choline = ADP + phosphocholine
ATP + ethanolamine = ADP + O-phosphoethanolamine
Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline/ethanolamine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 401 amino acids
Theoretical weight: 46.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y259 (Residues: 14-395; Coverage: 97%)
Gene names: CHETK, CHKB, CHKL
Sequence domains: Choline/ethanolamine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand UNX 24 x UNX
1 modified residue:
Ligand MSE 22 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 52.657Å b: 109.208Å c: 157.952Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.227
Expression system: Escherichia coli

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