› 2ipr

X-ray diffraction
1.5Å resolution

Origin binding domain of the SV40 large T antigen (residues 131-259). P21 crystal form

Released:
DOI: 10.2210/pdb2ipr/pdb
PDB entry 2ipr coloured by chain, front view.
PDB entry 2ipr coloured by chain, side view.
PDB entry 2ipr coloured by chain, top view.
Source organism: Macaca mulatta polyomavirus 1
Primary publication:
Structure of the origin-binding domain of simian virus 40 large T antigen bound to DNA.
Bochkareva E, Martynowski D, Seitova A, Bochkarev A
EMBO J 25 5961-9 (2006)
PMID: 17139255

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189169 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Large T antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 133 amino acids
Theoretical weight: 15.38 KDa
Source organism: Macaca mulatta polyomavirus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q98ZP7 (Residues: 131-259; Coverage: 24%)
Sequence domains: Origin of replication binding protein
Structure domains: Replication Protein E1; Chain: A,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 37.715Å b: 56.633Å c: 59.889Å
α: 90° β: 97.13° γ: 90°
R-values:
R R work R free
0.179 0.178 0.204
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

The Mcm complex: unwinding the mechanism of a replicative helicase.
Bochman et al. (2009)
5 more

7 mentions without citation

The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.
Ou et al. (2011)
6 more