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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain

X-ray diffraction
1.89Å resolution
PDB entry 2iug coloured by chain, front view.
PDB entry 2iug coloured by chain, side view.
PDB entry 2iug coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 3-kinase regulatory subunit alpha
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-151131

Macromolecules

Phosphatidylinositol 3-kinase regulatory subunit alpha
Chain: A
Length: 120 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P27986 (Residues: 321-440; Coverage: 17%)
Gene names: GRB1, PIK3R1
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 2iug, assembly 1, front view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 2iug, assembly 1, side view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 2iug, assembly 1, top view.
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