› 2izs

X-ray diffraction
1.95Å resolution

Structure of casein kinase gamma 3 in complex with inhibitor

Released:
DOI: 10.2210/pdb2izs/pdb
PDB entry 2izs coloured by chain, front view.
PDB entry 2izs coloured by chain, side view.
PDB entry 2izs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bunkoczi G, Salah E, Rellos P, Das S, Fedorov O, Savitsky P, Debreczeni JE, Gileadi O, Sundstrom M, Edwards A, Arrowsmith C, Weigelt J, von Delft F, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform gamma-3 Chain: A
Molecule details ›
Chain: A
Length: 330 amino acids
Theoretical weight: 38.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6M4 (Residues: 35-362; Coverage: 73%)
Gene name: CSNK1G3
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand BRQ 1 x BRQ
Ligand MG 2 x MG
Ligand CL 2 x CL
Ligand PGO 1 x PGO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P3121
Unit cell:
a: 56.029Å b: 56.029Å c: 220.089Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.179 0.234
Expression system: Escherichia coli BL21(DE3)

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