› 2jcn

X-ray diffraction
1.8Å resolution

The crystal structure of BAK1 - a mitochondrial apoptosis regulator

Released:
DOI: 10.2210/pdb2jcn/pdb
PDB entry 2jcn coloured by chain, front view.
PDB entry 2jcn coloured by chain, side view.
PDB entry 2jcn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Moche M, Stenmark P, Arrowsmith C, Berglund H, Busam R, Collins R, Edwards A, Ericsson UB, Flodin S, Flores A, Graslund S, Hammarstrom M, Hallberg BM, Holmberg Schiavone L, Johansson I, Karlberg T, Kosinska U, Kotenyova T, Lundgren S, Nilsson ME, Nyman T, Ogg D, Persson C, Sagemark J, Sundstrom M, Uppenberg J, Upsten M, Thorsell AG, van den Berg S, Weigelt J, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2 homologous antagonist/killer Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16611 (Residues: 21-190; Coverage: 81%)
Gene names: BAK, BAK1, BCL2L7, CDN1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P6522
Unit cell:
a: 62.77Å b: 62.77Å c: 138.07Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.232
Expression system: Escherichia coli BL21(DE3)

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