EC 1.15.1.1: Superoxide dismutase
Reaction catalysed:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Systematic name:
Superoxide:superoxide oxidoreductase
Alternative Name(s):
- Copper-zinc superoxide dismutase
- Cu,Zn-SOD
- Cu-Zn superoxide dismutase
- Cuprein
- Cytocuprein
- Erythrocuprein
- Fe-SOD
- Ferrisuperoxide dismutase
- Hemocuprein
- Hepatocuprein
- Mn-SOD
- SOD
- SOD-1
- SOD-2
- SOD-3
- SOD-4
- SODF
- SODS
- Superoxidase dismutase
- Superoxide dismutase I
- Superoxide dismutase II
GO terms
Biochemical function:
Biological process:
- negative regulation of cellular respiration
- protein stabilization
- positive regulation of transcription by RNA polymerase II
- cellular response to oxidative stress
- fungal-type cell wall organization
- removal of superoxide radicals
- protein maturation by copper ion transfer
- intracellular zinc ion homeostasis
- intracellular copper ion homeostasis
- superoxide metabolic process
Cellular component:
Sequence family
Protein family (Pfam)
![The deposited structure of PDB entry 2jcw contains 1 copy of Pfam domain PF00080 (Copper/zinc superoxide dismutase (SODC)) in Superoxide dismutase [Cu-Zn]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2jcw_1_A_Pfam_PF00080_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2jcw</span> contains 1 copy of Pfam domain <span class='highlight'>PF00080 (Copper/zinc superoxide dismutase (SODC))</span> in <span class='highlight'>Superoxide dismutase [Cu-Zn]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
InterPro annotations
IPR036423
Domain description:
Superoxide dismutase-like, copper/zinc binding domain superfamily
Occurring in:
Occurring in:
CATH domain![The deposited structure of PDB entry 2jcw contains 1 copy of CATH domain 2.60.40.200 (Immunoglobulin-like) in Superoxide dismutase [Cu-Zn]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2jcw_1_A_CATH_2.60.40.200_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2jcw</span> contains 1 copy of CATH domain <span class='highlight'>2.60.40.200 (Immunoglobulin-like)</span> in <span class='highlight'>Superoxide dismutase [Cu-Zn]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
SCOP annotation![The deposited structure of PDB entry 2jcw contains 1 copy of SCOP domain 49330 (Cu,Zn superoxide dismutase-like) in Superoxide dismutase [Cu-Zn]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2jcw_1_A_SCOP_49330_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2jcw</span> contains 1 copy of SCOP domain <span class='highlight'>49330 (Cu,Zn superoxide dismutase-like)</span> in <span class='highlight'>Superoxide dismutase [Cu-Zn]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")