› 2jn5

Solution NMR

Solution Structure of a Dodecapeptide from Alpha-Synuclein Bound with Synphilin-1

Released:
DOI: 10.2210/pdb2jn5/pdb
PDB entry 2jn5 coloured by chain, ensemble of 10 models, front view.
PDB entry 2jn5 coloured by chain, ensemble of 10 models, side view.
PDB entry 2jn5 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.
Xie YY, Zhou CJ, Zhou ZR, Hong J, Che MX, Fu QS, Song AX, Lin DH, Hu HY
FASEB J 24 196-205 (2010)
PMID: 19762560

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chain: A
Molecule details ›
Chain: A
Length: 12 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P37840 (Residues: 1-12; Coverage: 9%)
Gene names: NACP, PARK1, SNCA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

5 review citations

Basic mechanisms of neurodegeneration: a critical update.
Jellinger KA. (2010)
4 more

1 mention without citation

In vitro aggregation assays for the characterization of α-synuclein prion-like properties.
Narkiewicz et al. (2014)