› 2jnu

Solution NMR

Solution structure of the RGS domain of human RGS14

Released:
DOI: 10.2210/pdb2jnu/pdb
PDB entry 2jnu coloured by chain, ensemble of 20 models, front view.
PDB entry 2jnu coloured by chain, ensemble of 20 models, side view.
PDB entry 2jnu coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP
Proc Natl Acad Sci U S A 105 6457-62 (2008)
PMID: 18434541

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of G-protein signaling 14 Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43566 (Residues: 56-207; Coverage: 27%)
Gene name: RGS14
Sequence domains: Regulator of G protein signaling domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Update on melatonin receptors: IUPHAR Review 20.
Jockers et al. (2016)
22 more

4 mentions without citation

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
Gileadi et al. (2007)
3 more