› 2jpd

Solution NMR

Solution structure of the ERCC1 central domain

Released:
DOI: 10.2210/pdb2jpd/pdb
PDB entry 2jpd coloured by chain, ensemble of 20 models, front view.
PDB entry 2jpd coloured by chain, ensemble of 20 models, side view.
PDB entry 2jpd coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization.
Tripsianes K, Folkers GE, Zheng C, Das D, Grinstead JS, Kaptein R, Boelens R
Nucleic Acids Res 35 5789-98 (2007)
PMID: 17720715

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139873 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA excision repair protein ERCC-1 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07992 (Residues: 96-219; Coverage: 42%)
Gene name: ERCC1
Sequence domains: Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Nucleotide excision repair in eukaryotes.
Schärer OD. (2013)
6 more

4 mentions without citation

DNA repair gets physical: mapping an XPA-binding site on ERCC1.
Croteau et al. (2008)
3 more