› 2jrc

Solution NMR

Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.

Released:
DOI: 10.2210/pdb2jrc/pdb
PDB entry 2jrc coloured by chain, ensemble of 40 models, front view.
PDB entry 2jrc coloured by chain, ensemble of 40 models, side view.
PDB entry 2jrc coloured by chain, ensemble of 40 models, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Solution structure and dynamics of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis H37Rv.
Pulavarti SV, Jain A, Pathak PP, Mahmood A, Arora A
J Mol Biol 378 165-77 (2008)
PMID: 18342886

Function and Biology Details

Reaction catalysed: 
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161572 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-tRNA hydrolase Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 22.01 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WHN7 (Residues: 1-191; Coverage: 100%)
Gene names: MTCY10G2.35, Rv1014c, pth
Sequence domains: Peptidyl-tRNA hydrolase
Structure domains: Peptidyl-tRNA hydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Structural and functional insights into peptidyl-tRNA hydrolase.
Sharma et al. (2014)
19 other articles

4 mentions without citation

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.
Kim et al. (2017)
3 more