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Solution NMR

The prokaryotic Cys2His2 zinc finger adopts a novel fold as revealed by the NMR structure of A. tumefaciens Ros DNA binding domain

Released:
DOI: 10.2210/pdb2jsp/pdb
PDB entry 2jsp coloured by chain, ensemble of 20 models, front view.
PDB entry 2jsp coloured by chain, ensemble of 20 models, side view.
PDB entry 2jsp coloured by chain, ensemble of 20 models, top view.
Source organism: Agrobacterium tumefaciens
Primary publication:
The prokaryotic Cys2His2 zinc-finger adopts a novel fold as revealed by the NMR structure of Agrobacterium tumefaciens Ros DNA-binding domain.
Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
Proc. Natl. Acad. Sci. U.S.A. 104 17341-6 (2007)
PMID: 17956987

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170000 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional regulatory protein ros Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.95 KDa
Source organism: Agrobacterium tumefaciens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04152 (Residues: 56-142; Coverage: 61%)
Gene name: ros
Sequence domains: ROS/MUCR transcriptional regulator protein
Structure domains: ROS/MUCR transcriptional regulator protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Versatility of global transcriptional regulators in alpha-Proteobacteria: from essential cell cycle control to ancillary functions.
Panis et al. (2015)
3 more

9 mentions without citation

Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer?
Jiao et al. (2020)
8 more