› 2jtk

Solution NMR

A functional domain of a Wnt signal protein

Released:
DOI: 10.2210/pdb2jtk/pdb
PDB entry 2jtk coloured by chain, ensemble of 20 models, front view.
PDB entry 2jtk coloured by chain, ensemble of 20 models, side view.
PDB entry 2jtk coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.
Chen L, Wang K, Shao Y, Huang J, Li X, Shan J, Wu D, Zheng JJ
J. Biol. Chem. 283 23364-70 (2008)
PMID: 18524778

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193058 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dickkopf-related protein 2 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.14 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9QYZ8 (Residues: 172-259; Coverage: 39%)
Gene name: Dkk2
Sequence domains:
Structure domains: Lipase, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets.
Baarsma et al. (2013)
11 more

6 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
5 more