Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Tyrosine-protein kinase ITK/TSK (preferred)
PDBe Complex ID:
PDB-CPX-169912 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase ITK/TSK
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 7.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Length: 63 amino acids
Theoretical weight: 7.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q03526 (Residues: 177-237; Coverage: 10%)
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Tyrosine-protein kinase ITK/TSK
Molecule details ›
Chain: B
Length: 110 amino acids
Theoretical weight: 12.68 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: SH2 domain
Structure domains: SH2 domain
Length: 110 amino acids
Theoretical weight: 12.68 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical: Q03526 (Residues: 238-344; Coverage: 17%)
Sequence domains: SH2 domain
Structure domains: SH2 domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
simulated annealing
Expression system: Escherichia coli
