› 2k9u

Solution NMR

Solution NMR structure of the Filamin-migfilin complex

Released:
DOI: 10.2210/pdb2k9u/pdb
PDB entry 2k9u coloured by chain, ensemble of 20 models, front view.
PDB entry 2k9u coloured by chain, ensemble of 20 models, side view.
PDB entry 2k9u coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Migfilin, a molecular switch in regulation of integrin activation.
Ithychanda SS, Das M, Ma YQ, Ding K, Wang X, Gupta S, Wu C, Plow EF, Qin J
J Biol Chem 284 4713-22 (2009)
PMID: 19074766

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171989 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Filamin-C Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14315 (Residues: 2302-2415; Coverage: 4%)
Gene names: ABPL, FLN2, FLNC
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins
Filamin-binding LIM protein 1 Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8WUP2 (Residues: 1-24; Coverage: 6%)
Gene names: FBLIM1, FBLP1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

27 review citations

Integrins.
Barczyk et al. (2010)
26 more

6 mentions without citation

Migfilin: Cell Adhesion Effect and Comorbidities.
Duan et al. (2022)
5 more