› 2kad

Solid-state NMR

Magic-Angle-Spinning Solid-State NMR Structure of Influenza A M2 Transmembrane Domain

Released:
DOI: 10.2210/pdb2kad/pdb
PDB entry 2kad coloured by chain, front view.
PDB entry 2kad coloured by chain, side view.
PDB entry 2kad coloured by chain, top view.
Source organism: Influenza A virus (A/Hong Kong/156/97(H5N1))
Primary publication:
Structure of amantadine-bound M2 transmembrane peptide of influenza A in lipid bilayers from magic-angle-spinning solid-state NMR: the role of Ser31 in amantadine binding.
Cady SD, Mishanina TV, Hong M
J Mol Biol 385 1127-41 (2009)
PMID: 19061899

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 25 amino acids
Theoretical weight: 2.69 KDa
Source organism: Influenza A virus (A/Hong Kong/156/97(H5N1))
Expression system: Not provided
UniProt:
  • Canonical: O70632 (Residues: 22-46; Coverage: 26%)
Gene name: M

Ligands and Environments

1 bound ligand:
Ligand 308 1 x 308
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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Citations

24 review citations

Structures of influenza A proteins and insights into antiviral drug targets.
Das et al. (2010)
23 more

14 mentions without citation

Approved Antiviral Drugs over the Past 50 Years.
De Clercq et al. (2016)
13 more