› 2kav

Solution NMR

Solution structure of the human Voltage-gated Sodium Channel, brain isoform (Nav1.2)

Released:
DOI: 10.2210/pdb2kav/pdb
PDB entry 2kav coloured by chain, ensemble of 15 models, front view.
PDB entry 2kav coloured by chain, ensemble of 15 models, side view.
PDB entry 2kav coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the NaV1.2 C-terminal EF-hand domain.
Miloushev VZ, Levine JA, Arbing MA, Hunt JF, Pitt GS, Palmer AG
J Biol Chem 284 6446-54 (2009)
PMID: 19129176

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel protein type 2 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99250 (Residues: 1777-1882; Coverage: 5%)
Gene names: HBA, NAC2, SCN2A, SCN2A1, SCN2A2
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology.
Abriel H. (2010)
6 more

9 mentions without citation

Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.
Kim et al. (2010)
8 more