› 2kbq

Solution NMR

Solution structure of harmonin N terminal domain

Released:
DOI: 10.2210/pdb2kbq/pdb
PDB entry 2kbq coloured by chain, ensemble of 20 models, front view.
PDB entry 2kbq coloured by chain, ensemble of 20 models, side view.
PDB entry 2kbq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23.
Pan L, Yan J, Wu L, Zhang M
Proc Natl Acad Sci U S A 106 5575-80 (2009)
PMID: 19297620

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195382 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Harmonin Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 9.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6N9 (Residues: 1-80; Coverage: 15%)
Gene names: AIE75, USH1C
Sequence domains: Harmonin, N-terminal domain
Structure domains: Paired amphipathic helix 2 (pah2 repeat)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

20 review citations

Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities.
Mathur et al. (2015)
19 more

6 mentions without citation

αα-Hub domains and intrinsically disordered proteins: A decisive combo.
Bugge et al. (2021)
5 more