› 2kk0

Solution NMR

Solution structure of dead ringer-like protein 1 (at-rich interactive domain-containing protein 3a) from homo sapiens, northeast structural genomics consortium (NESG) target hr4394c

Released:
DOI: 10.2210/pdb2kk0/pdb
PDB entry 2kk0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2kk0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2kk0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target.
Liu G, Huang YJ, Xiao R, Wang D, Acton TB, Montelione GT
Proteins 78 2170-5 (2010)
PMID: 20455271

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AT-rich interactive domain-containing protein 3A Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99856 (Residues: 218-351; Coverage: 23%)
Gene names: ARID3A, DRIL1, DRIL3, DRX, E2FBP1
Sequence domains: ARID/BRIGHT DNA binding domain
Structure domains: ARID DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: molecular dynamics, distance geometry, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 review citation

ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery.
Guo et al. (2023)
6 other articles

4 mentions without citation

Communication routes in ARID domains between distal residues in helix 5 and the DNA-binding loops.
Invernizzi et al. (2014)
3 more