› 2kk6

Solution NMR

Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d

Released:
DOI: 10.2210/pdb2kk6/pdb
PDB entry 2kk6 coloured by chain, ensemble of 20 models, front view.
PDB entry 2kk6 coloured by chain, ensemble of 20 models, side view.
PDB entry 2kk6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Tang Y, Wang D, Nwosu C, Owens L, Xiao R, Liu J, Baran MC, Swapna G, Acton TB, Rost B, Montelione GT, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147773 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fer Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16591 (Residues: 453-557; Coverage: 13%)
Gene names: FER, TYK3
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli

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