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Solution NMR

Solution NMR structure of the homodimeric winged helix-turn-helix DNA-binding domain (fragment 1-100) Mb0332 from Mycobacterium bovis, a possible ArsR-family transcriptional regulator. Northeast Structural Genomics Consortium Target MbR242E.

Released:
DOI: 10.2210/pdb2kko/pdb
PDB entry 2kko coloured by chain, ensemble of 20 models, front view.
PDB entry 2kko coloured by chain, ensemble of 20 models, side view.
PDB entry 2kko coloured by chain, ensemble of 20 models, top view.
Source organism: Mycobacterium tuberculosis variant bovis
Entry authors: Ramelot TA, Cort JR, Wang D, Ciccosanti C, Jiang M, Nair R, Rost B, Swapna G, Acton TB, Xiao R, Everett JK, Montelione GT, Kennedy MA, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162827 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY) Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 11.75 KDa
Source organism: Mycobacterium tuberculosis variant bovis
Expression system: Escherichia coli
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 46%
Refinement method: simulated annealing
Expression system: Escherichia coli

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