› 2kkw

Hybrid

SLAS-micelle bound alpha-synuclein

Released:
DOI: 10.2210/pdb2kkw/pdb
PDB entry 2kkw coloured by chain, ensemble of 34 models, front view.
PDB entry 2kkw coloured by chain, ensemble of 34 models, side view.
PDB entry 2kkw coloured by chain, ensemble of 34 models, top view.
Source organism: Homo sapiens
Primary publication:
A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins.
Rao JN, Jao CC, Hegde BG, Langen R, Ulmer TS
J Am Chem Soc 132 8657-68 (2010)
PMID: 20524659

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein
Structure domains: Helix hairpin bin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Experimental Method: EPR, Solution NMR
Expression system: Escherichia coli

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Citations

18 review citations

Biophysics of α-synuclein membrane interactions.
Pfefferkorn et al. (2012)
17 more

34 mentions without citation

Scratching the surface: native mass spectrometry of peripheral membrane protein complexes.
Sahin et al. (2020)
33 more