› 2kll

Solution NMR

Solution structure of human interleukin-33

Released:
DOI: 10.2210/pdb2kll/pdb
PDB entry 2kll coloured by chain, ensemble of 10 models, front view.
PDB entry 2kll coloured by chain, ensemble of 10 models, side view.
PDB entry 2kll coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.
Lingel A, Weiss TM, Niebuhr M, Pan B, Appleton BA, Wiesmann C, Bazan JF, Fairbrother WJ
Structure 17 1398-410 (2009)
PMID: 19836339

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132016 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-33 (109-270) Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95760 (Residues: 111-270; Coverage: 59%)
Gene names: C9orf26, IL1F11, IL33, NFHEV
Sequence domains: Interleukin 33
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Overview of the IL-1 family in innate inflammation and acquired immunity.
Dinarello CA. (2018)
51 more

12 mentions without citation

Structural Basis of IL-1 Family Cytokine Signaling.
Fields et al. (2019)
11 more