› 2klz

Solution NMR

Solution Structure of the Tandem UIM Domain of Ataxin-3 Complexed with Ubiquitin

Released:
DOI: 10.2210/pdb2klz/pdb
PDB entry 2klz coloured by chain, ensemble of 10 models, front view.
PDB entry 2klz coloured by chain, ensemble of 10 models, side view.
PDB entry 2klz coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Entry authors: Zhou C, Song A, Lin D, Hu H

Function and Biology Details

Reaction catalysed: 
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156965 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ataxin-3 Chain: A
Molecule details ›
Chain: A
Length: 52 amino acids
Theoretical weight: 6.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54252 (Residues: 222-263; Coverage: 12%)
Gene names: ATX3, ATXN3, MJD, MJD1, SCA3
Sequence domains: Ubiquitin interaction motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

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