› 2knj

Solution NMR

NMR structure of microplusin a antimicrobial peptide from Rhipicephalus (Boophilus) microplus

Released:
DOI: 10.2210/pdb2knj/pdb
PDB entry 2knj coloured by chain, ensemble of 15 models, front view.
PDB entry 2knj coloured by chain, ensemble of 15 models, side view.
PDB entry 2knj coloured by chain, ensemble of 15 models, top view.
Source organism: Rhipicephalus microplus
Primary publication:
Structure and mode of action of microplusin, a copper II-chelating antimicrobial peptide from the cattle tick Rhipicephalus (Boophilus) microplus.
Silva FD, Rezende CA, Rossi DC, Esteves E, Dyszy FH, Schreier S, Gueiros-Filho F, Campos CB, Pires JR, Daffre S
J Biol Chem 284 34735-46 (2009)
PMID: 19828445

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antimicrobial peptide microplusin Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.22 KDa
Source organism: Rhipicephalus microplus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86LE5 (Residues: 21-110; Coverage: 100%)
Structure domains: DNA polymerase; domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

6 review citations

Interaction of the tick immune system with transmitted pathogens.
HajduĊĦek et al. (2013)
5 more

2 mentions without citation

Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy.
Mercer et al. (2020)
1 more