› 2koy

Solution NMR

Structure of the E1064A mutant of the N-domain of Wilson Disease Associated Protein

Released:
DOI: 10.2210/pdb2koy/pdb
PDB entry 2koy coloured by chain, ensemble of 20 models, front view.
PDB entry 2koy coloured by chain, ensemble of 20 models, side view.
PDB entry 2koy coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of copper-transporting ATPase ATP7B.
Dmitriev OY, Bhattacharjee A, Nokhrin S, Uhlemann EM, Lutsenko S
J Biol Chem 286 16355-62 (2011)
PMID: 21398519

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WND/140 kDa Chain: A
Molecule details ›
Chain: A
Length: 141 amino acids
Theoretical weight: 14.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35670 (Residues: 1036-1196; Coverage: 9%)
Gene names: ATP7B, PWD, WC1, WND
Sequence domains: haloacid dehalogenase-like hydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Golgi in copper homeostasis: a view from the membrane trafficking field.
Polishchuk et al. (2013)
4 more

2 mentions without citation

Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of copper-transporting ATPase ATP7B.
Dmitriev et al. (2011)
1 more