› 2kqb

Solution NMR

First PBZ domain of human APLF protein

Released:
DOI: 10.2210/pdb2kqb/pdb
PDB entry 2kqb coloured by chain, ensemble of 25 models, front view.
PDB entry 2kqb coloured by chain, ensemble of 25 models, side view.
PDB entry 2kqb coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Eustermann S, Brockmann C, Mehrotra PV, Yang JC, Loakes D, West SC, Ahel I, Neuhaus D
Nat Struct Mol Biol 17 241-3 (2010)
PMID: 20098424

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aprataxin and PNK-like factor Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 10.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IW19 (Residues: 368-451; Coverage: 16%)
Gene names: APLF, C2orf13, PALF, XIP1
Sequence domains: PBZ domain

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications.
Polo et al. (2011)
34 more

3 mentions without citation

Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Eustermann et al. (2010)
2 more