Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Peptidylproline (omega=180) = peptidylproline (omega=0)
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169855 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MLL cleavage product N320; Peptidyl-prolyl cis-trans isomerase E
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Alpha-Beta Plaits
Length: 140 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q03164 (Residues: 1585-1628; Coverage: 1%) - Canonical: Q9UNP9 (Residues: 2-82; Coverage: 27%)
Sequence domains:
Structure domains: Alpha-Beta Plaits
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
simulated annealing, molecular dynamics
Expression system: Escherichia coli
