› 2kx5

Solution NMR

Recognition of HIV TAR RNA by peptide mimetic of Tat protein

Released:
DOI: 10.2210/pdb2kx5/pdb
PDB entry 2kx5 coloured by chain, ensemble of 10 models, front view.
PDB entry 2kx5 coloured by chain, ensemble of 10 models, side view.
PDB entry 2kx5 coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein.
Davidson A, Patora-Komisarska K, Robinson JA, Varani G
Nucleic Acids Res 39 248-56 (2011)
PMID: 20724442

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-162850 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Cyclic peptide mimetic of Tat protein Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 2.27 KDa
Source organism: Synthetic construct
Expression system: Not provided
HIV TAR RNA Chain: A
Molecule details ›
Chain: A
Length: 29 nucleotides
Theoretical weight: 9.31 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DPR 1 x DPR

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

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Citations

9 review citations

Constraining cyclic peptides to mimic protein structure motifs.
Hill et al. (2014)
8 more

11 mentions without citation

Deep structural insights into RNA-binding disordered protein regions.
Zeke et al. (2022)
10 more