› 2kzt

Solution NMR

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176087 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Programmed cell death protein 4 Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 17.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q53EL6 (Residues: 157-318; Coverage: 35%)
Gene names: H731, PDCD4
Sequence domains: MA3 domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Programmed cell death protein 4 Chain: B
Molecule details ›
Chain: B
Length: 131 amino acids
Theoretical weight: 15.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q61823 (Residues: 319-449; Coverage: 28%)
Gene names: Ma3, Pdcd4, Tis
Sequence domains: MA3 domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: HADDOCK
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The role of Pdcd4 in tumour suppression and protein translation.
Wang et al. (2018)
22 other articles

1 mention without citation

Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor.
Waters et al. (2011)