› 2l2v

Solution NMR

NMR Solution Structures of -3 (3' staggered) Bistranded Abasic Site Lesions in DNA

Released:
DOI: 10.2210/pdb2l2v/pdb
PDB entry 2l2v coloured by chain, ensemble of 4 models, front view.
PDB entry 2l2v coloured by chain, ensemble of 4 models, side view.
PDB entry 2l2v coloured by chain, ensemble of 4 models, top view.
Source organism: Synthetic construct
Primary publication:
NMR solution structures of clustered abasic site lesions in DNA: structural differences between 3'-staggered (-3) and 5'-staggered (+3) bistranded lesions.
Hazel RD, de los Santos C
Biochemistry 49 8978-87 (2010)
PMID: 20825249

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115518 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA_(5'-D(*CP*AP*GP*CP*TP*AP*TP*GP*(3DR)P*GP*AP*AP*GP*C)-3')_ Chain: A
Molecule details ›
Chain: A
Length: 14 nucleotides
Theoretical weight: 4.18 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA_(5'-D(*GP*CP*TP*TP*CP*AP*CP*AP*(3DR)P*AP*GP*CP*TP*G)-3')_ Chain: B
Molecule details ›
Chain: B
Length: 14 nucleotides
Theoretical weight: 4.13 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, molecular dynamics
Expression system: Not provided

Quick links

Citations

4 citation in other articles

Impact of bistrand abasic sites and proximate orientation on DNA global structure and duplex energetics.
Minetti et al. (2018)
3 more