› 2l34

Solution NMR

Structure of the DAP12 transmembrane homodimer

Released:
DOI: 10.2210/pdb2l34/pdb
PDB entry 2l34 coloured by chain, ensemble of 15 models, front view.
PDB entry 2l34 coloured by chain, ensemble of 15 models, side view.
PDB entry 2l34 coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis for intramembrane assembly of an activating immunoreceptor complex.
Call ME, Wucherpfennig KW, Chou JJ
Nat Immunol 11 1023-9 (2010)
PMID: 20890284

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129164 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TYRO protein tyrosine kinase-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 33 amino acids
Theoretical weight: 3.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43914 (Residues: 35-67; Coverage: 36%)
Gene names: DAP12, KARAP, TYROBP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli

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Citations

26 review citations

New insights into the T cell synapse from single molecule techniques.
Dustin et al. (2011)
25 more

10 mentions without citation

A view into the blind spot: solution NMR provides new insights into signal transduction across the lipid bilayer.
Call et al. (2010)
9 more