› 2l43

Solution NMR

Structural basis for histone code recognition by BRPF2-PHD1 finger

Released:
DOI: 10.2210/pdb2l43/pdb
PDB entry 2l43 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l43 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l43 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Qin S, Zhang J, Wu J, Shi Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131986 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 1; Histone H3.3 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 9.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P84243 (Residues: 2-16; Coverage: 11%)
  • Canonical: O95696 (Residues: 205-269; Coverage: 6%)
Gene names: BRD1, BRL, BRPF2, H3-3A, H3-3B, H3.3A, H3.3B, H3F3, H3F3A, H3F3B, PP781
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli

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