› 2l53

Solution NMR

Solution NMR Structure of apo-calmodulin in complex with the IQ motif of Human Cardiac Sodium Channel NaV1.5

Released:
DOI: 10.2210/pdb2l53/pdb
PDB entry 2l53 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l53 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l53 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5.
Chagot B, Chazin WJ
J Mol Biol 406 106-19 (2011)
PMID: 21167176

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162863 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Sodium channel protein type 5 subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 31 amino acids
Theoretical weight: 3.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14524 (Residues: 1901-1927; Coverage: 1%)
Gene name: SCN5A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Structural diversity of calmodulin binding to its target sites.
Tidow et al. (2013)
17 more

21 mentions without citation

Calmodulin and Ca(2+) control of voltage gated Na(+) channels.
Gabelli et al. (2016)
20 more