› 2l5i

Solution NMR

structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form)

Released:
DOI: 10.2210/pdb2l5i/pdb
PDB entry 2l5i coloured by chain, ensemble of 8 models, front view.
PDB entry 2l5i coloured by chain, ensemble of 8 models, side view.
PDB entry 2l5i coloured by chain, ensemble of 8 models, top view.
Source organism: Homo sapiens
Primary publication:
The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells.
Page N, Schall N, Strub JM, Quinternet M, Chaloin O, Décossas M, Cung MT, Van Dorsselaer A, Briand JP, Muller S
PLoS One 4 e5273 (2009)
PMID: 19390596

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140242 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U1 small nuclear ribonucleoprotein 70 kDa Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.57 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08621 (Residues: 131-151; Coverage: 5%)
Gene names: RNPU1Z, RPU1, SNRNP70, SNRP70, U1AP1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

15 review citations

HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.
Stricher et al. (2013)
14 more

2 mentions without citation

Forcefield_PTM: Ab Initio Charge and AMBER Forcefield Parameters for Frequently Occurring Post-Translational Modifications.
Khoury et al. (2013)
1 more