› 2l60

Solution NMR

A novel design concept: New Y-receptor agonists with increased membrane recruitment, Y2 affinity and selectivity

Released:
DOI: 10.2210/pdb2l60/pdb
PDB entry 2l60 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l60 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l60 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Pedersen NL, Jurt S, Zerbe O, Jensen KJ

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145158 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptide YY(3-36) Chain: A
Molecule details ›
Chain: A
Length: 41 amino acids
Theoretical weight: 5.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10082 (Residues: 32-64; Coverage: 48%)
Gene name: PYY
Sequence domains: Pancreatic hormone peptide
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Refinement method: torsion angle dynamics
Expression system: Not provided

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