› 2l71

Solution NMR

NMR solution structure of GIP in Bicellular media

Released:
DOI: 10.2210/pdb2l71/pdb
PDB entry 2l71 coloured by chain, ensemble of 15 models, front view.
PDB entry 2l71 coloured by chain, ensemble of 15 models, side view.
PDB entry 2l71 coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide.
Venneti KC, Malthouse JP, O'Harte FP, Hewage CM
Biochim Biophys Acta 1814 882-8 (2011)
PMID: 21539943

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gastric inhibitory polypeptide Chain: A
Molecule details ›
Chain: A
Length: 42 amino acids
Theoretical weight: 4.99 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09681 (Residues: 52-93; Coverage: 32%)
Gene name: GIP
Sequence domains: Peptide hormone

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 51%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP.
Wang L. (2022)
1 more