› 2l87

Solution NMR

The 27-residue N-terminus CCR5-peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide

Released:
DOI: 10.2210/pdb2l87/pdb
PDB entry 2l87 coloured by chain, ensemble of 10 models, front view.
PDB entry 2l87 coloured by chain, ensemble of 10 models, side view.
PDB entry 2l87 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide.
Schnur E, Noah E, Ayzenshtat I, Sargsyan H, Inui T, Ding FX, Arshava B, Sagi Y, Kessler N, Levy R, Scherf T, Naider F, Anglister J
J Mol Biol 410 778-97 (2011)
PMID: 21763489

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C chemokine receptor type 5 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 3.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P51681 (Residues: 1-27; Coverage: 8%)
Gene names: CCR5, CMKBR5

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TYS 2 x TYS

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors.
Szpakowska et al. (2012)
1 more

5 mentions without citation

Molecular recognition of CCR5 by an HIV-1 gp120 V3 loop.
Tamamis et al. (2014)
4 more