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X-ray diffraction
2.96Å resolution

CHARACTERIZATION OF THE ANTIGENIC SITES ON THE REFINED 3-ANGSTROMS RESOLUTION STRUCTURE OF MOUSE TESTICULAR LACTATE DEHYDROGENASE C4

Released:
DOI: 10.2210/pdb2ldx/pdb
PDB entry 2ldx coloured by chain, front view.
PDB entry 2ldx coloured by chain, side view.
PDB entry 2ldx coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Characterization of the antigenic sites on the refined 3-A resolution structure of mouse testicular lactate dehydrogenase C4.
Hogrefe HH, Griffith JP, Rossmann MG, Goldberg E
J Biol Chem 262 13155-62 (1987)
PMID: 2443489

Function and Biology Details

Reaction catalysed: 
(S)-lactate + NAD(+) = pyruvate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132415 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate dehydrogenase C chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 331 amino acids
Theoretical weight: 35.87 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P00342 (Residues: 2-332; Coverage: 100%)
Gene names: Ldh-3, Ldh3, Ldhc
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 84.8Å b: 76.6Å c: 63.9Å
α: 109.7° β: 89.5° γ: 96.5°
R-values:
R R work R free
0.256 not available not available
Expression system: Not provided

Quick links

Citations

2 review citations

LDHC: the ultimate testis-specific gene.
Goldberg et al. (2010)
1 more

6 mentions without citation

The Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients.
Gupta GS. (2022)
5 more