› 2le7

Solution NMR

Solution nmr structure of the S4S5 linker of herg potassium channel

Released:
DOI: 10.2210/pdb2le7/pdb
PDB entry 2le7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2le7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2le7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.
Ng CA, Perry MD, Tan PS, Hill AP, Kuchel PW, Vandenberg JI
PLoS One 7 e31640 (2012)
PMID: 22359612

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily H member 2 Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.33 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q12809 (Residues: 532-551; Coverage: 2%)
Gene names: ERG, ERG1, HERG, KCNH2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: GENERALISED BORN ENERGY MINIMIZATION WITH NMR RESTRAINTS, DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

5 review citations

Development of Safe Drugs: The hERG Challenge.
Kalyaanamoorthy et al. (2018)
4 more

2 mentions without citation

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.
Ng et al. (2012)
1 more