› 2lk9

Solution NMR

Structure of BST-2/Tetherin Transmembrane Domain

Released:
DOI: 10.2210/pdb2lk9/pdb
PDB entry 2lk9 coloured by chain, front view.
PDB entry 2lk9 coloured by chain, side view.
PDB entry 2lk9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions.
Skasko M, Wang Y, Tian Y, Tokarev A, Munguia J, Ruiz A, Stephens EB, Opella SJ, Guatelli J
J Biol Chem 287 58-67 (2012)
PMID: 22072710

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171238 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone marrow stromal antigen 2 Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q10589 (Residues: 18-47; Coverage: 17%)
Gene name: BST2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 19%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

27 review citations

The restriction factors of human immunodeficiency virus.
Harris et al. (2012)
26 more

4 mentions without citation

Multi-functional BST2/tetherin against HIV-1, other viruses and LINE-1.
Zhao et al. (2022)
3 more