› 2lmj

Solution NMR

Itk-sh3

Released:
DOI: 10.2210/pdb2lmj/pdb
PDB entry 2lmj coloured by chain, ensemble of 20 models, front view.
PDB entry 2lmj coloured by chain, ensemble of 20 models, side view.
PDB entry 2lmj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Kristiansen P, Bie Andersen T, Huszenicza Z, Andreotti AH, Spurkland A

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q08881 (Residues: 171-231; Coverage: 10%)
Gene names: EMT, ITK, LYK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21

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