› 2lna

Solution NMR

Solution NMR Structure of the mitochondrial inner membrane domain (residues 164-251), FtsH_ext, from the paraplegin-like protein AFG3L2 from Homo sapiens, Northeast Structural Genomics Consortium Target HR6741A

Released:
DOI: 10.2210/pdb2lna/pdb
PDB entry 2lna coloured by chain, ensemble of 20 models, front view.
PDB entry 2lna coloured by chain, ensemble of 20 models, side view.
PDB entry 2lna coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure and MD simulations of the AAA protease intermembrane space domain indicates peripheral membrane localization within the hexaoligomer.
Ramelot TA, Yang Y, Sahu ID, Lee HW, Xiao R, Lorigan GA, Montelione GT, Kennedy MA
FEBS Lett 587 3522-8 (2013)
PMID: 24055473

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195252 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial inner membrane m-AAA protease component AFG3L2 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 11.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y4W6 (Residues: 164-251; Coverage: 11%)
Gene name: AFG3L2
Sequence domains: FtsH Extracellular
Structure domains: name from scop

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.
Muller et al. (2019)
2 more

6 mentions without citation

Multifunctional Mitochondrial AAA Proteases.
Glynn SE. (2017)
5 more