Function and Biology Details
Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Tensin-2 and Rho GTPase-activating protein 7 (preferred)
PDBe Complex ID:
PDB-CPX-179045 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tensin-2
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Phosphotyrosine-binding domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Length: 147 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q63HR2 (Residues: 1263-1409; Coverage: 10%)
Sequence domains: Phosphotyrosine-binding domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Rho GTPase-activating protein 7
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
78%
Refinement method:
torsion angle dynamics, molecular dynamics
Expression system: Escherichia coli
