› 2lp0

Solution NMR

The solution structure of homeodomain-protein complex

Released:
DOI: 10.2210/pdb2lp0/pdb
PDB entry 2lp0 coloured by chain, ensemble of 10 models, front view.
PDB entry 2lp0 coloured by chain, ensemble of 10 models, side view.
PDB entry 2lp0 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for homeodomain recognition by the cell-cycle regulator Geminin.
Zhou B, Liu C, Xu Z, Zhu G
Proc Natl Acad Sci U S A 109 8931-6 (2012)
PMID: 22615398

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130997 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Homeobox protein Hox-C9 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 7.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31274 (Residues: 192-251; Coverage: 23%)
Gene names: HOX3B, HOXC9
Sequence domains: Homeodomain
Structure domains: Homeodomain-like
Geminin Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75496 (Residues: 171-190; Coverage: 10%)
Gene name: GMNN

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: torsion angle dynamics, simulated annealing, molecular dynamics
Expression system: Escherichia coli

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Citations

8 review citations

Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets.
Collins et al. (2016)
7 more

1 mention without citation

Structural basis for homeodomain recognition by the cell-cycle regulator Geminin.
Zhou et al. (2012)