› 2lpn

Solution NMR

Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)

Released:
DOI: 10.2210/pdb2lpn/pdb
PDB entry 2lpn coloured by chain, ensemble of 20 models, front view.
PDB entry 2lpn coloured by chain, ensemble of 20 models, side view.
PDB entry 2lpn coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
(1)H-, (13)C- and (15)N-NMR assignment of the N-terminal domain of human cerebral dopamine neurotrophic factor (CDNF).
Latgé C, Cabral KM, Almeida MS, Foguel D
Biomol NMR Assign 7 101-3 (2013)
PMID: 22528768

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cerebral dopamine neurotrophic factor Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q49AH0 (Residues: 27-131; Coverage: 64%)
Gene names: ARMETL1, CDNF
Sequence domains: ARMET, N-terminal
Structure domains: Saposin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential.
Lindahl et al. (2017)
2 more