› 2lq6

Solution NMR

Solution structure of BRD1 PHD2 finger

Released:
DOI: 10.2210/pdb2lq6/pdb
PDB entry 2lq6 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lq6 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lq6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA.
Liu L, Qin S, Zhang J, Ji P, Shi Y, Wu J
J Struct Biol 180 165-73 (2012)
PMID: 22820306

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95696 (Residues: 317-394; Coverage: 7%)
Gene names: BRD1, BRL, BRPF2
Sequence domains: PHD-zinc-finger like domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Functional and cancer genomics of ASXL family members.
Katoh M. (2013)
8 more

5 mentions without citation

Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.
Klein et al. (2014)
4 more